2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Monoamine Transporter

Monoamine Transporter

Monoamine Transporter

Related Products

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Monoamine transporters (MATs) belong to the solute carrier 6 (SLC6) family of human transporters, which, in turn, is a subfamily of the broader neurotransmitter:sodium symporters (NSSs) that comprise transporters from prokaryotic to human. MATs comprise three main members-the dopamine (DA) transporter (DAT), serotonin transporter (SERT) and norepinephrine transporter (NET). MATs regulate neurotransmission via the reuptake of dopamine, serotonin and norepinephrine from extra-neuronal regions and thus maintain neurotransmitter homeostasis.

MATs are transmembrane proteins located in plasma membranes of monoaminergic neurons. These proteins use ion (Na+, Cl−) gradients as energy sources to move monoamines into or out of neurons. In the membrane of intracellular synaptic vesicles is the vesicular monoamine transporters 1 and 2 (VMAT1 and VMAT2), which use a proton gradient as the energy source to sequester cytosolic monoamines into the vesicles and then release the monoamines into synaptic cleft by exocytosis. Dysregulation of MATs has been linked to depression, anxiety disorder, attention-deficit-hyperactivity disorder, obsessive-compulsive disorder, substance-use disorders, epilepsy, Parkinson’s disease and autism-spectrum disorder. Thus, MATs serve as pharmacological targets for several neuropsychiatric and neurodegenerative disorders.

Monoamine Transporter Related Products (59):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N7506
    13-Hydroxyisobakuchiol
    		Inhibitor
    Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression.
    13-Hydroxyisobakuchiol
  • HY-173398
    NMDAR antagonist 5
    		Antagonist
    NMDAR antagonist 5 (Compound A17) is a multi-target antagonist against NMDAR and monoamine transporters (SERT、DAT and NET). NMDAR antagonist 5 shows good NMDAR antagonistic potency (IC50 = 0.3 μM) and monoamine transporter activities (SERT IC50 = 1.1 μM、DAT IC50 = 0.7 μM、NET IC50 = 2.7 μM). NMDAR antagonist 5 is highly safe and has low toxicity (hepatotoxicity and nephrotoxicity (IC50 > 100 μM); cardiotoxicity (IC50 = 24.5 μM)). NMDAR antagonist 5 has antidepressant effects and can be used in the study of depression.
    NMDAR antagonist 5
  • HY-107956
    Imipramine pamoate
    Imipramine pamoate is a potent anti-depressant compound.
    Imipramine pamoate
  • HY-W681822
    (R,S,S)-Dihydrotetrabenazine
    		Inhibitor
    (R,S,S)-Dihydrotetrabenazine (R,S,S-DHTBZ) is a kind of discrete isomeric secondary alcohol metabolites of Tetrabenazine (TBZ, HY-B0590), is a poor VMAT2 inhibitor (Ki = 690 nM).
    (R,S,S)-Dihydrotetrabenazine
  • HY-141554A
    (2S,3S,11bR)-Dihydrotetrabenazine
    		Inhibitor
    (2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR)-Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR)-Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders.
    (2S,3S,11bR)-Dihydrotetrabenazine
  • HY-172029
    3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride
    3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT)，serotonin transporter (SERT)，and the norepinephrine transporter (NET).
    3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride
  • HY-W743021
    4-Methyl-α-ethyltryptamine
    4-Methyl-α-ethyltryptamine is a homolog of α-Ethyltryptamine. α-Ethyltryptamine alters monoamine release and re-uptake in the brain.
    4-Methyl-α-ethyltryptamine
  • HY-120788
    VMAT2-IN-4
    		Inhibitor
    VMAT2-IN-4 (compound 11) is a vesicular monoamine transporter-2 (VMAT2) inhibitor. VMAT2-IN-4 inhibits [3H]-DTBZ binding (Ki = 560 nM). VMAT2-IN-4 inhibits [3H]-DA (Ki = 45 nM) from entering vesicles and being taken up by cells. VMAT2-IN-4 can be used in methamphetamine addiction research.
    VMAT2-IN-4
  • HY-103465B
    FFN511 hydrochloride
    		Inhibitor
    FFN511 (hydrochloride) is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 (hydrochloride) inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 (hydrochloride) directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices.
    FFN511 hydrochloride
  • HY-B0590R
    Tetrabenazine (Standard)
    		Inhibitor
    Tetrabenazine (Standard) is the analytical standard of Tetrabenazine. This product is intended for research and analytical applications. Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.
    Tetrabenazine (Standard)
  • HY-152171
    GZ-11608
    		Inhibitor
    GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with high affinity (Ki = 25 nM). GZ-11608 decreases methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons. GZ-11608 exhibits rapid brain penetration and without neurotoxicity. GZ-11608 can be used for the research of methamphetamine use disorder.
    GZ-11608
  • HY-B1704R
    Nisoxetine (Standard)
    		Inhibitor
    Nisoxetine (Standard) is the analytical standard of Nisoxetine. This product is intended for research and analytical applications. Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels.
    Nisoxetine (Standard)
  • HY-135022
    3-Bromoamphetamine hydrochloride
    3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that acts as a monoamine releasing agent.
    3-Bromoamphetamine hydrochloride
  • HY-N0480AR
    Reserpine hydrochloride (Standard)
    		Inhibitor
    Reserpine (hydrochloride) (Standard) is the analytical standard of Reserpine (hydrochloride). This product is intended for research and analytical applications. Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
    Reserpine hydrochloride (Standard)
  • HY-16771R
    Valbenazine (Standard)
    		Inhibitor
    Valbenazine (Standard) is the analytical standard of Valbenazine. This product is intended for research and analytical applications. Valbenazine (NBI-98854) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with the Ki of 110-190 nM.
    Valbenazine (Standard)
  • HY-W354635
    N-Methyl-2-phenylpropan-1-amine hydrochloride
    N-Methyl-2-phenylpropan-1-amine hydrochloride is a β-Methylphenethylamine (BMPEA) analog, and has transmitter releasing action at NET and DAT assay.
    N-Methyl-2-phenylpropan-1-amine hydrochloride
  • HY-N0480R
    Reserpine (Standard)
    		Inhibitor
    Reserpine (Standard) is the analytical standard of Reserpine. This product is intended for research and analytical applications. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
    Reserpine (Standard)
  • HY-19907
    Liafensine
    		Inhibitor 99.46%
    Liafensine (BMS-820836) is a triple monoamine reuptake inhibitor (TRI), that inhibits dopamine transporter, serotonin transporter and norepinephrine transporter, with IC50s of 5.67, 1.08 and 7.99 nM, respectively. Liafensine exhibits antidepressant activity.
    Liafensine
  • HY-B0590D
    (-)-Tetrabenazine
    		Inhibitor
    (-)-Tetrabenazine ((-)-TBZ; compound 13) is an enantiomer of Tetrabenazine (HY-B0590). (+)-Tetrabenazine proves 3-fold more active than (-)-Tetrabenazine in inhibiting vesicular monoamine transporter 2 (VMAT2).
    (-)-Tetrabenazine